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Show Notes
On this episode of the molpigs Podcast we introduce the new members of the molpigs team and re-introduce the long-term hosts, Boya Wang and Erik Poppleton. Hannah and Georgeos have stepped down from the podcast team, though Hannah continues to support us from behind the scenes. Joining us today are our two new members, Spencer Winter and Anuhya Edupuganti. On this episode we interview each other about why we're here, our strengths, our dreams, and why you should host boardgame nights at DNA conferences.
Errata
A couple of factual errata:
- When Erik is talking about annealing ramps for DNA origami crystal assemblies, he says that they use a zigzag temperature around the nucleation temperature. In fact, they just ran extremely slow annealing ramps around the nucleation temperature (see the SI of the paper linked below)
- The word for the plant cellular structure that Erik can't remember is plasmodesmata, not desmosome.
Links
Links to the papers discussed in this episode:
- Anuhya's favorite paper: Isothermal self-assembly of multicomponent and evolutive DNA nanostructures by Rossi-Gendron et. al. (2023)
- Spencer's favorite paper: A deoxyribozyme-based molecular automaton by Stojanovic & Stefanovic (2003)
- Boya's favorite paper: Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades by Qian & Winfree (2011)
- Erik's favorite paper: Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies by Shaw et. al. (2019)
Erik also mentioned a series of other papers which use similar ideas in nanopatterning to study biological systems:
- Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers
- Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides
- Role of nanoscale antigen organization on B-cell activation probed using DNA origami
- DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases
- Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination
The papers on crystal assembly: